RPCI holds accreditations or certifications from many organizations, including:

• National Cancer Institute-designated comprehensive cancer center
• National Comprehensive Cancer Network
• Commission on Cancer of the American College of Surgeons
• Joint Commission on Accreditation of Healthcare Organizations
• Foundation for the Accreditation of Cellular Therapy
• National Marrow Donor Program (as a Transplant, Apheresis and Collection Center)
• American Dental Association – Dentistry and Maxillofacial Prosthetics
• Myelodysplastic Syndrome Foundation Center of Excellence
• Society of Surgical Oncology – Surgical Oncology Training Program
• Association of American Blood Banks
• Accreditation Council for Continuing Medical Education
• Accreditation Council for Graduate Medical Education