Selected Peer-reviewed Publications

Cao X, Deng X, May WS. Cleavage of Bax to p18 Bax accelerates stress-induced apoptosis, and a cathepsin-like protease may rapidly degrade p18 Bax. Blood. 2003.102 (7): 2605-14.

Kem WR, Mahnir VM, Prokai L, Papke RL, Cao X, LeFrancois S, Wildeboer K, Prokai-Tatrai K, Porter-Papke J, Soti F. Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions with brain nicotinic receptors, and brain penetration. Molecular Pharmacology. 2004. 65 (1): 56-67.

Revell PA, Grossman WJ, Thomas DA, Cao X, Behl R, Ratner JA. Lu ZH, Ley TJ. Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions. J Immunol. 2005 Feb 15; 174(4): 2124-31.

Raja SM, Metkar SS, Honing S, Wang B, Russin WA, Pipalia NH, Menaa C, Belting M, Cao X, Dressel R, Froelich CJ. A novel mechanism for protein delivery: granzyme B undergoes electrostatic exchange from serglycin to target cells. J Biol Chem. 2005 May 27; 280(21): 20752-61.

Fehniger TA, Cai SF, Cao X, Bredemeyer AJ, Presti RM, French AR, Ley TJ. Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs. Immunity. 2007 Jun; 26(6):798-811.

Cao X, Cai SF, Fehniger TA, Song J, Collins LI, Piwnica-Worms D, Ley TJ. Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. Immunity. 2007 Oct; 27(4):635-46.

Cao X, Bennett RL, May WS. c-Myc and caspase-2 are involved in activating Bax during cytotoxic drug-induced apoptosis. J Biol Chem. 2008 May 23; 283( 21):14490-96

Cai SF, Fehniger TA, Cao X, Mayer JC, Brune J, French A, Ley TJ. Differential expression of granzyme B and C in murine cytotoxic lymphocytes. J Immunol. 2009 May 15;182(10):6287-97

Cao X. Regulatory T cells and immune tolerance to tumors. Immunologic Research. In Press.

Cao X, Leonard K, Collins LI, Cai SF, Mayer JC, Payton JE, Walter MJ, Piwnica-Worms D, Schreiber RD, Ley TJ. IL-12 stimulates interferon-gamma mediated inhibition of tumor-induced regulatory T cell proliferation and enhances tumor clearance. Cancer Research. In Press.