April 17, 2007
AACR On Site Contact: Catherine Donnelly
 

BUFFALO, NY – High intake of iron, combined with low intake of dietary antioxidants, may increase prostate cancer risk, according to results of a study to be presented by Ji-Yeob Choi, PhD, Department of Cancer Prevention and Population Control, Roswell Park Cancer Institute (RPCI) at the 2007 centennial meeting of the American Association for Cancer Research (AACR), April 14-18, in Los Angeles, CA.

“Iron Intake, Genetic Polymorphisms in Myeloperoxidase and Manganese Superoxide Dismutase, and Prostate Cancer Risk in CARET Cohort,” Embargoed until Tuesday, April 17, 12:10 pm PST

            Room 501 A-C, Los Angeles Convention Center

A study was based on the Carotene and Retinol Efficacy Trial (CARET) cohort of 661 men who subsequently developed prostate cancer and 1,360 healthy men.The CARET was a National Cancer Institute funded multicenter, randomized chemoprevention trial.

Those men who consumed higher amounts of dietary iron were found to be at increased risk of clinically aggressive prostate cancer; this risk was strongest among men who consumed fewer fruits and vegetables. When genetics were examined in relation to diet and prostate cancer risk, the researchers found that men with genotypes that are related to higher levels of oxidative species − which can damage DNA − and who consumed the highest levels of dietary iron, were at the greatest risk of prostate cancer, and this was strongest for men diagnosed with clinically aggressive disease.       

Founded in 1907, the American Association for Cancer Research is the world’s oldest and largest professional organization dedicated to advancing cancer research. Members include more than 24,000 basic, translational and clinical researchers, health care professionals, and cancer survivors and advocates in the United States and more than 60 other countries.

Roswell Park Cancer Institute, founded in 1898, is the nation’s first cancer research, treatment and education center and is the only National Cancer Institute-designated comprehensive cancer center in Upstate New York. RPCI is a member of the prestigious National Comprehensive Cancer Network, an alliance of the nation’s leading cancer centers. Roswell Park has affiliate sites and collaborative programs in New York, Pennsylvania, and in China. For more information, visit RPCI’s website at www.roswellpark.org, call 1-877-ASK-RPCI (1-877-275-7724) or e-mail askrpci@roswellpark.org.

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