2006

 

1. Luo, W., Kageshita, T., Wakasugi, S., Wang, X., Karpf, A. R., and S. Ferrone. (2006). Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells. Oncogene 25, 2873-2884.

 

2. Godert, A. M., Angelino, N., Woloszynska-Read, A., Morey, S. R., James, S. R., Karpf, A. R., and J. R. Sufrin. (2006). An improved synthesis of Psammaplin A. Bioorg Med Chem Lett 16, 3330-3333.

 

3. James, S. R., P. A. Link, and A. R. Karpf. (2006). Epigenetic regulation of X-linked cancer/germ-line antigen genes by DNMT1 and DNMT3b. Oncogene 25, 6975-6985.

 

4. Karpf, A. R. (2006). A potential role for epigenetic modulatory drugs in the enhancement of cancer/germ-line antigen vaccine efficacy. Epigenetics 1, 116-120.

 

5. K.Rai, L. D. Nadauld, S. Chidester, E. J. Manos, S. R. James, A. R. Karpf, B. R. Cairns, and D. A. Jones. (2006). Zebra Fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during development. Mol Cell Biol 126, 7077-7085.

 

6. Esteve, P-O. , Chin, H. G., Smallwood, A., Gangisetty, O., Karpf, A. R., Carey, M. F., and S. Pradhan. (2006). Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during DNA replication. Genes and Development 20, 3089-3103.

 

7. Morey, S. R., Smiraglia, D. J., James,S. R., Yu, J., Moser, M. T., Foster, B. A., and A. R. Karpf. (2006). DNA methylation pathway alterations in an autochthonous murine model of prostate cancer. Cancer Research 66, 11659-67.

 

2007

 

1. Rai, K., Chidester, S., Zvala, C. V., Manos, E. J., James, S. R., Karpf, A. R., Jones, D. A., and B. R. Cairns. (2007). Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish. Genes and Development. 21, 261-266.

 

2. Chung, I., A. R. Karpf, J. R. Muindi, J. M. Conroy, N. J. Nowak, C. S. Johnson, and D. L. Trump. (2007). Epigenetic silencing of Cyp24 in tumor-derived endothelial cells contributes to selective growth inhibition by calcitrol. J Biol Chem. 282, 8704-8714.

 

3. Karpf, A. R. (2007). Epigenomic reactivation screening to identify genes silenced by DNA hypermethylation in human cancer. Current Opinion in Molecular Therapeutics. 9, 231-241.

 

4. Karpf, A. R. (2007). Cancer Germline (CG) Antigens. Encyclopedia of Cancer, 2^nd Edition. M. Schwab, Editor. Springer, Heidelberg, Germany. In Press.

 

5. Chung, I, Yu, W. D, Karpf, A. R., Flynn, G., Bernardi, R. J., Modzelewski, R. A., Johnson, C. S., Trump, D. L. (2007). Anti-proliferative effects of calcitrol on endothelial cells derived from two different microenvironments. J Steriod Biochem Mol Biol. 103, 768-770.

 

6. Woloszynska-Read, A, James, S. R., Link, P. A., Yu, J., Odunsi, K., and A. R. Karpf. (2007). DNA methylation-dependent regulation of BORIS/CTCFL expression in ovarian cancer. Cancer Immunity, 7:21.

 

2008

1. Bagnyukova, T. V., Tryndyak, V. P., Montgomery, B., Churchwell, M. I., Karpf, A. R., James, S. R., Muskhelishvili, L., Beland, F. A., and I. P. Pogribny. (2008). Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene. Carcinogenesis 29, 638-46.

2. Woloszynska-Read, A, Mhawech-Fauceglia, P., Yu, J., Odunsi, K., and A. R. Karpf. (2008). Intertumor and intratumor NY-ESO-1 expression heterogeneity is associated with promoter-specific and global DNA methylation status in ovarian cancer. Clin Cancer Res. 14, 3283-90.

3. Camoriano M, Kinney SR, Moser MT, Foster BA, Mohler JL, Trump DL, Karpf AR, Smiraglia DJ. Phenotype-specific CpG island methylation events in a murine model of prostate cancer. Cancer Res. 68, 4173-82.

4. Morey Kinney SR, Smiraglia DJ, James SR, Moser MT, Foster BA, Karpf AR. Stage-specific alterations of DNA methyltransferase expression, DNA hypermethylation, and DNA hypomethylation during prostate cancer progression in the transgenic adenocarcinoma of mouse prostate model. Mol Cancer Res.6, 1365-74.

5. Pogribny IP, Karpf AR, James SR, Melnyk S, Han T, Tryndyak VP. Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet. Brain Research, 1237, 25-34.  

6. Link PA, Baer MR, James SR, Jones DA, Karpf AR. p53-inducible ribonucleotide reductase (p53R2/RRM2B) is a DNA hypomethylation-independent decitabine gene target that correlates with clinical response in MDS/AML. Cancer Res 2008; 68: (22). November 15, 2008.

7. Rai K, Huggins IJ, James SR, Karpf AR, Jones DA, Cairns BR. DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Cell. 2008 Dec 26; 135(7):1201-12.

 

2009

1. Adam R. Karpf, Suxia Bai, Smitha R. James, James L. Mohler, and Elizabeth M. Wilson. Promoter DNA hypomethylation and cyclic AMP regulation of androgen receptor coregulator MAGE-11 in prostate cancer.  Mol Cancer Res. 7, 523-535.

2. Mavis CK, Kinney SR, Foster BA, Karpf AR.Expression level and DNA methylation status of glutathione-S-transferase genes in normal murine prostate and TRAMP tumors. Prostate. 2009 May 14. [Epub ahead of print]

3. Link, P. A., Gangisetty, O., James, S. R., Woloszynska-Read, A., Tachibana, M., Shinkai, Y., and A. R. Karpf. (2009). Distinct roles for histone methyltransferases G9a and GLP in cancer germline antigen gene regulation in human cancer cells and murine ES cells. Molecular Cancer Research, 7(6), June 2009.

4. Choi, J-Y., James, S. R., Link, P. A., McCann, S. E., Hong, C-C., Davis, W., Nesline, M. K., Ambrosone, C. B., and A. R. Karpf. (2009). Association between global DNA hypomethylation in leukocytes and risk of breast cancer. Carcinogenesis, In Press