Kakati, Surabhi, PhD

Research Associate, Cytogenetics Lab
Roswell Park Cancer Institute
Phone: (716) 845-4411
Fax: (716) 845-8298
email: surabhi.kakati@roswellpark.org

Assistant Research Professor
State University of New York at Buffalo

Dr. Surabhi Kakati joined the staff of Roswell Park Cancer Institute (RPCI) in 1973. She earned her doctoral degree in Cytogenetics at Banaras Hindu University, India (1970) and completed postdoctoral training at the Robert A. Welch Foundation, Baylor College of Medicine, Houston, TX (1973).

Dr. Kakati's major research interest is chromosome study in human cancers, especially leukemia. She has authored or co-authored over 80 publications, book chapters and abstracts.

General Research Interest
The objective of our research is to understand the relationships between chromosomal abnormalities and the genetic events occurring in cancers. Structural and numerical chromosomal abnormalities are characteristic of leukemias, lymphomas, and solid tumors. The final chromosomal profile, or karyotype, is obtained using computer assisted image analysis software, after the biological material has been subjected to various chromosomal banding techniques, including spectral karyotyping. Chromosomal abnormalities are associated with the molecular activation and modification of oncogene expression. These molecular events are detected using fluorescence in situ hybridization (FISH) techniques, including chromosomal painting with DNA probes.
The objective of our research is to understand the relationships between chromosomal abnormalities and the genetic events occurring in cancers. Structural and numerical chromosomal abnormalities are characteristic of leukemias, lymphomas, and solid tumors. The final chromosomal profile, or karyotype, is obtained using computer assisted image analysis software, after the biological material has been subjected to various chromosomal banding techniques, including spectral karyotyping. Chromosomal abnormalities are associated with the molecular activation and modification of oncogene expression. These molecular events are detected using fluorescence in situ hybridization (FISH) techniques, including chromosomal painting with DNA probes.
Key Publications:

FELIX CA, MEGONIGAL MD, CHERVINSKY DS, LEONARD DGB, TSUCHIDA N,

KAKATI S, BLOCK A, FISHER J, GROSSI M, SALHANY KI, SAIT SNJ, APLAN PD. Association of germline P53 mutation with MLL segmental jumping translocation in treatment-related leukemia. Genes Chrom. Cancer 91:4451-4456, 1998.

NAYAK SK, KAKATI S, HARVEY SR, MALONE CC, DILLMAN RO. Characterization of cancer cell lines established from two human metastatic breast cancers. In Vitro 36:188-193, 2000.